In this post on the Flash Purification Blog, Bob Bickler discusses the impact of elution solvent choice on both normal and reversed-phase purification. He concludes:
"So, to get the best flash purification results, evaluate various strong solvents and solvent ratios with miscible weak solvents during method development. You may be pleasantly surprised with the results."
SPE Protocol for Extraction of Urinary Catecholamines and Metanephrines
Extraction of Benzodiazepines From Oral Fluid Using ISOLUTE® SLE+
A Beginner's Guide to Flash Purification of Peptides
How Solvent Choice Impacts Flash Chromatography Performance
Extraction of Teicoplanin from Plasma Using EVOLUTE® EXPRESS ABN Prior to HPLC-DAD Analysis