The protocol described is optimized for the 1 mL capacity ISOLUTE SLE+ column format. The simple sample preparation procedure delivers clean extracts and analyte recoveries greater than 70% with RSDs lower than 10% for all analytes.
ISOLUTE® SLE+ Supported Liquid Extraction plates and columns offer an efficient alternative to traditional liquid-liquid extraction (LLE) for bioanalytical sample preparation, providing high analyte recoveries, no emulsion formation, and significantly reduced sample preparation.
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This concludes the Biotage Application Note series covering extraction of all the major drug classes from NeoSal oral fluid collection devices.