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Extraction of 49 Illicit Drugs of Abuse from Whole Blood Using ISOLUTE® SLE+

20 February 2017

This application note describes the extraction of 49 drugs of abuse from whole blood, prior to UPLC-MS/MS analysis.

 

An effective and efficient ISOLUTE SLE+ protocol optimized the for 1 mL sample capacity column formats is described in this application note. The simple sample preparation procedure delivers clean extracts, good recoveries and RSD values and LLOQ from 10 ng/mL.

ISOLUTE® SLE+ Supported Liquid Extraction columns offer an efficient alternative to traditional liquid-liquid extraction (LLE) for bioanalytical sample preparation, providing high analyte recoveries, no emulsion formation, and significantly reduced sample preparation.

Download the Application Note Below »

 

Analytes

  • 2-OH-ethyl-flurazepam
  • 6-MAM
  • 7-amino-clonazepam
  • 7-amino-flunitrazepam
  • Alprazolam
  • Amphetamine
  • Benzoylecgonine
  • Bromazepam
  • Buprenorphine
  • Clonazepam
  • Cocaine
  • Codeine
  • Diazepam
  • Dihydrocodeine
  • EDDP
  • Estazolam
  • Fentanyl
  • Flunitrazepam
  • Flurazepam
  • Hydrocodone
  • Hydromorphone
  • Ketamine
  • Lorazepam
  • LSD
  • MDA
  • MDEA
  • MDMA
  • Mephedrone
  • Methadone
  • Methamphetamine
  • Midazolam
  • Morphine
  • Nitrazepam
  • Norbuprenorphine
  • Nordiazepam
  • Norfentanyl
  • Norketamine
  • Oxazepam
  • Oxycodone
  • Oxymorphone
  • PCP
  • Temazepam
  • THC-COOH
  • Triazolam
  • Zaleplone
  • Zolpidem
  • Zopiclone
  • α-OH-alprazolam
  • α-OH-triazolam

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ISOLUTE® SLE+ Supported Liquid Extraction