Extraction of Antiepileptic Drugs from Human Urine, Serum and Oral Fluid Using Supported Liquid Extraction (ISOLUTE® SLE+) in 96-Well Plate Prior to LC-MS-MS
Part No: P074
Issued year: 2014
File size: 0.52mb
File type: pdf
Antiepileptic drugs are prescribed to suppress seizures in epilepsy patients. A variety of different types of AEDs have been synthesized to pharmacologically address different types of epilepsy. The ability to therapeutically monitor these drugs in patients is necessary for maintaining optimal medical care and managing any adverse effects of thedrug. A fast and clean extraction method is needed that works in a variety of biological
matrices and affords a high throughput workflow. In this poster, ISOLUTE SLE+ is demonstrated as an effective way to extract AEDs from serum, oral fluid and urine with good efficiency and recovery. The method was developed on a 96 well plate format to facilitate a high throughput workflow model.
MSACL 2014
96-well plate
Antiepileptics
Carbamazepine 10,11 epoxide
Clinical
English
Felbamate
Gabapentin
LC-MS/MS
Oral fluid
Oxcarbazepine
Posters
Rufinamide
Saliva
Serum
Tigabatine
Urine
Vigabatrin