Part No: AN738Issued year: 2011File size: 0.27mbFile type: pdf
The screening for elevated levels of Methylmalonic Acid (MMA) in serum is commonly used as a clinical diagnostic indicator of Cobalamin (Vitamin B12) deficiency in mammals. The significance of this screening is important for the detection of inborn metabolic disorders that can lead to the build up MMA in human biological systems. The detection and quantification of MMA can be problematic due to the abundant presence of the endogenous isobaric Succinic Acid (SA). The SA offers no clinical diagnostic value. This application note demonstrates analyte recoveries >90% with RSDs <10%.
Serum, Clinical, MMA, Methylmalonic acid, SLE, SLE+, supported liquid extraction,