Part No: P044Issued year: 2012File size: 0.89mbFile type: pdf
The objective was to develop a GC-MS assay for the determination of free benzodiazepines using Supported Liquid Extraction (SLE). The SLE extraction mechanism is very efficient, delivering higher analyte recoveries and cleaner extracts than equivalent LLE methods.
ISOLUTE, SLE, SLE+, Supported Liquid Extraction, Benzodiazepines, Forensic, Drugs, DOA, Drugs of Abuse, SOFT,
Part No: Issued year: 2016File size: 0.94mbFile type: pdf
Cortisol measurement in hair samples scan be a useful indicator of chronic stress. This poster compares a new LC-MS/MS method with an existing immunoassay based method.
The Biotage Bead Ruptor is used effectively for hair pre-treatment.
Part No: PPS498Issued year: 2018File size: 0.9mbFile type: pdf
PeptiDream Inc. relocated their head office in August 2017 and established its new research
center in the Kawasaki City International Strategic Center. The expanded facility is expected
to spawn innovative new drugs. The base instrumentation is provided by Biotage. R&D
Director Keichi Masuya and his staff elaborate on the development.
Part No: P159Issued year: 2017File size: 0.25mbFile type: pdf
When it comes to polar organic compound purification,
many chemists turn to normal-phase flash
chromatography often utilizing dichloromethane and
methanol as the eluting solvents. While this can work, it
often can be challenging to optimize due to methanol’s
high polarity and protic chemistry.
Part No: MSACL US 2018 Breakfast SeminarIssued year: 2018File size: 3.24mbFile type: pdf
The use of LC/MS analysis in the clinical lab has increased exponentially over the last 10 years. Modern mass spectrometers are extremely sensitive allowing low level detection of many target analytes. However, this sensitivity can come at a price, in that levels of contamination not previously detected with less sensitive instruments can now have larger impact on analysis. The complexity of common matrices such as plasma/serum and urine while presenting different challenges can have a marked influence on method performance.
As a result sample preparation is an extremely important part of the process in order to provide robust methods. This seminar focuses on some of the method development challenges our lab faced when looking at two clinical assays:
Endogenous steroid hormone extraction from serum, and catecholamine extraction from plasma and urine.
Particular emphasis is placed on the various sample preparation options we looked at for the extraction of these analytes. During optimization of the extraction process we investigated analyte recovery, co-extractable matrix components, HPLC column degradation, calibration curve performance and limits of quantitation.
MSACL US 2018 Breakfast Seminar
Part No: TN-0022.0207Issued year: 2007File size: 0.08mbFile type: pdf
ACTU Preparation of PS-HOBt(HL). 2-Chloro-1,1,3,3 tetramethyluronium hexachloroantimonate (ACTU) is a reagent which allows polymer-supported active esters of PS-HOBt(HL) to be prepared in pure DMF. ACTU addresses the problem that many carboxylic acids are not soluble in DCM.
Part No: PPS457Issued year: 2017File size: 0.02mbFile type: xlsx
Use this simple tool to look up possible adducts and fragments which may occur with Isolera™ Dalton or Biotage® Dalton 2000 mass detectors.
Enter the target compound weight and use the mass lookup cell to highlight resulting m/z values.
Part No: Issued year: 2008File size: 0.2mbFile type: pdf
Advancer Kilobatch provides up to 12 hours unattended processing of homogenous reaction mixtures delivering kilogram quantities of your target compound. In addition, the system
will accommodate heterogeneous reactions by processing four sequential cycles (250 mL) to yield a 1 L batch. Through simple solid loading replenishment, kilogram quantities of
complex heterogeneous reactions are easily achieved.